Applications of Cryo-Electron Tomography in Health
The cellular environment is characterized by the presence of many different molecular species, where macromolecular complexes, stable or transient, underlie critical cellular functions. Cryo-Electron Tomography (cryo-ET) is an extension of the technique that was Nobel awarded in Chemistry in 2017, cryo-Electron Microscopy (cryo-EM). With faithful sample preservation and direct imaging of fully hydrated biological material, cryo-ET enables an accurate three-dimensional (3D) visualization and analysis of the subcellular architecture at unprecedented resolution and in situ, i.e. under native conditions and preserving functional interactions.
Cryo-ET is very a sophisticated multidisciplinary technique so only few research groups in Europe hold the expertise. This workshop has the purpose of connecting experts in cryo-ET with biomedical researchers and biochemist in order to identify possible applications of cryo-ET to solve long standing questions in health at molecular level.
Contexte
In general, any scientist interested in applying cryo-Electron Tomography to solve a scientific question in health area. Experts in cryo-Electron Microscopy are also encouraged to participate.
Objectifs visés
Firstly, the workshop will be the first contact for the nascent cryo-ET community within EUniWell. Secondly, it will allow to increase the value and impact of the methods developed by cryoET experts. Finally, it may allow to find novel solutions to long-standing open question in Health.
Démarche mise en œuvre
Every participant has to give a talk to introduce his expertise and latest results. There will be two roles: cryo-ET experts with technological solutions, and biochemical or medical experts with open questions to solve. At the end, there will be a roundtable where all participants will try to identify possible relevant health questions to solve by applied cryo-ET.
Ressources mobilisées
One day online workshop
Bilan et perspectives
